Zymox Advanced Otic Plus
Top PickWhat We Like
- No pre-cleaning of painful ears
- Enzymatic formula with 1% hydrocortisone
- One bottle covers a seven-day course
- Strongest relief results here
Worth Noting
- Small 1.25 oz bottle
- Highest per-ounce cost here
- Size
- 1.25 fl oz
- Course
- Once daily for 7 days
- Format
- Enzymatic drops
- Hydrocortisone
- 1%
Read the full review
Read the directions before you buy this one. Zymox tells you to fill an uncleaned ear canal, massage the base, wipe away the overflow, and repeat once a day for seven days, with no pre-cleaning and no flush afterward. That isn't a shortcut, it's the design, and it's why this is the bottle we reach for when a dog is mid-flare-up and won't let anyone near a sore ear with a cotton pad.
The formula pairs the LP3 enzyme system with 1% hydrocortisone, aimed at the itching and redness as well as the gunk. Because of the hydrocortisone it's a course rather than a habit: seven days, then switch to a routine flush if the ear still needs maintaining. Head shaking is usually the first thing to go, and it tends to go early in the course rather than at the end.
It is also the most consistent product in this set. Relief, ease of use, and odor control all sit at the top of this group, and there is no dimension where the feedback turns negative. That's rare here; most of the flushes have one thing that splits them.
The trade-off is size and scope. A 1.25-ounce bottle is a week of treatment, not a household staple, and per ounce it's the most expensive thing in this guide. Keep a routine flush for maintenance and this for the weeks when something is plainly wrong, and both bottles earn their shelf space.
Bottom line: If your dog's ears are yeasty, itchy, and sore to touch, this seven-day enzymatic course is the one we hand over before anything else in the lineup.